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  Ergotamine

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Alpha adrenergic blocking agent


Pharmacokinetics

Ergotamine is erratically absorbed from the GIT.Oral absorption is incomplete.It undergoes extensive first pass metabolism.



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Indications

Ergotamine has alpha adrenergic blocking and vasoconstrictor properties . It is effective in migraine and tension headache.



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Routes of Administration and Dosage

Oral and sublingual dosage forms- Adults: For relieving migraine; 1 mg is given at 30 minutes intervals till relief is obtained or a total of 6 mg is given.Dose of ergot should not exceed 10 mgs per week. For preventing cluster headaches : The dose of ergotamine, and the number of doses needed every day, will depend on the frequency of headaches/day. Usually 1 or 2 mg of ergotamine once a day may be enough, or if necessary 1 or 2 mg of ergotamine 2 or 3 times a day. For all uses: a total of 6 mg of ergotamine a day is the maximum permissible dose. For rectal suppository dosage forms- Adults: For relieving migraine or cluster headaches usually 1 mg of ergotamine, but the dose can range from 1/2 of this amount to up to 2 mg. If headache is not relieved, and there are no adverse effects, a second dose and even a third dose may be taken; however the doses should be taken at least 30 minutes apart. Adults should not use more than 4 mg of ergotamine a day in suppository form. This drug should not be used more than 2 times a week, at least five days apart. Children 6 years of age and older- For relieving migraine headaches: 1/2 mg or 1 mg of ergotamine. Children should not be administered more than 1 mg a day of ergotamine in suppository form. This drug should not be used more often than 2 times a week, at least five days apart.



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Contra Indications

Ergotamine is contraindicated in hypertension, vascular and valvular heart disease, pregnancy, septic conditions, cachexia, collagen disorders and fibrotic disease.



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Precautions

The chance of adverse effects may be increased in patients with Hypertension, pruritis, renal disease, hepatic disease, Mental depression, hyperthyroidism, intestinal obstruction and Urinary tract obstruction.



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Interactions

When it is used along with Cocaine or parenteral Epinephrine adverse effects caused by ergotamine may be increased



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Brand Names

Ergotamine combination brands: Migranil(Inga), Migril(Burroughs Wellcome), Vasograin(Cadila Pharma).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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