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  Erythromycin

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems All Systems
Category Antibacterial (Macrolide Antibiotic)


Pharmacokinetics

Erythromycin is absorbed from the small intestine, the drug gets partially destroyed by the gastric juice so it must be administered in enteric coated form. It is mainly concentrated in the bile.



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Indications

Erythromycin is a bacteriostatic drug. It is used to treat Respiratory Tract Infections,Chlamydial infections, diptheria, and acne vulgaris. Erythromycins are also used to prevent Streptococcal infections in patients with a history of rheumatic heart disease who may be allergic to penicillin.These drugs may also be used to treat Legionnaires' disease.



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Routes of Administration and Dosage

For erythromycin base: For oral dosage forms (capsules, tablets): For treatment of infections:Adults and teenagers: 250 to 500 milligrams (mg) two to four times a day. Children : Dose is based on body weight - 7.5 to 12.5 mg per kilogram (kg) of body weight four times a day, or 15 to 25 mg per kg of body weight two times a day. For prevention of cardiac infections: Adults : 1 gram two hours before surgery, then 500 mg six hours after taking the first dose. Children: The usual dose is 20 mg per kg of body weight two hours before surgery, then 10 mg per kg of body weight six hours after taking the first dose.



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Contra Indications

Contraindications are hypersensitivity, jaundice and pregnancy.



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Precautions

In cardiac disease: High doses of erythromycin may increase the chance of adverse effects in patients with a history of an arrhythmias. Hepatic disease :Erythromycins, especially erythromycin estolate, may increase the chance of adverse effects involving the liver. Loss of hearing : High doses of erythromycins may, on rare occasion, cause hearing loss and ototoxicity, especially in renal or hepatic disease.



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Interactions

With Acetaminophen, Amiodarone or Anabolic steroids, Androgens, antithyroid agents, Carmustine, Chloroquine, Dantrolene, Daunorubicin, Disulfiram, Divalproex, Estrogens, Gold salts, Hydroxychloroquine, Mercaptopurine, Methotrexate, Methyldopa, Naltrexone: Use of these drugs with erythromycins, especially erythromycin estolate, may increase the incidence of hepatic disorders.



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Brand Names

Althrocin( Alembic), Citamycin(Citadel), E-Mycin(Themis Pharma), E.E.S 400(Abbott), Eltocin(Ind-Swift), Eroate(Lupin), Eromed(Comed Chemicals), Erybest(Blue Cross), Eryc-C (BDH), Erycin(Alpine), Eryman(Maan Pharma), Erymer(Mercury), Erynate(Hindustan Antibiotics), Eryspans(American Remedies), Eryster( Hindustan Antibiotics), Erythrocin (Abbott), Etomin(SunPharma), Rekcin(Rekvina Labs), Resprocin(Indo French), Restomycin(Atsra-DL), Thromycin (IDPL).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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