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  Flurbiprofen

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Musculoskeletal System
Category NSAID-Propionic acid derivative.


Pharmacokinetics

Flurbiprofen, when given orally is highly plasma protein bound (about 90- 99%). It gets metabolised in the liver. It has a t1/2 of 4- 6 hrs.About 10% gets excreted in the urine. Flurbiprofen enters the brain, synovial fluid and can cross the placenta.



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Indications

Flurbiprofen is mainly used as an ocular anti-inflammatory agent.



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Routes of Administration and Dosage

0.03% eyedrops, 1 drop 6 hourly.



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Contra Indications

Flurbiprofen is contraindicated in hypersensitivity, active peptic ulcer, moderate to severe hepatic disease,bronchial asthma, ulcerative colitis, angioedema, asthma and in infants .



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Precautions

Special precaution has to be taken in patients with history of cardiac decompensation, hypertention, pregnancy and impaired renal function.



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Interactions

Flurbiprofen when used with lithium and Methotrexate, increases their toxicity. Flurbiprofen antagonises the effect of diuretics like Frusemide and Thiazides. It can delay the action of Digoxin.



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Brand Names

Arflur(FDC), Flurofen(Hoechst Marion Roussel), Froben(Knoll Pharma), Froben FR(Knoll Pharma).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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