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  Fosinopril

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions


Systems Cardiovascular system
Category ACE Inhibitor


Pharmacokinetics

Fosinopril is a recently introduced drug, its pharmocokinetics is similar to that of captopril. It is rapidly absorbed after oral administration with high bioavailability . It is highly protein bound. It is excreted via the urine.



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Indications

ACE inhibitors belong to the class of drugs called antihypertensives. Hypertension adds to the work load of the heart and arteries. If it continues for a long time, the heart and arteries may not function effectively. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, cardiac failure, or renal failure. Hypertension may also increase the risk of MI. These problems may be less likely to occur if blood pressure is controlled. Fosinopril is used in some patients after a MI. It is also used to treat congestive heart failure.



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Routes of Administration and Dosage

For oral dosage form (tablets): For hypertension: Adults: 10 to 40 mg once a day.



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Contra Indications

Contraindicated in hypersensitivity, Pregnancy, renal artery stenosis, renal impairment and angioedema.



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Precautions

Fosinopril causes the foetus to be smaller than normal. Studies in animals have shown that Fosinopril causes foetal death, probably due to severe hypotension.



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Interactions

Risk of bone marrow depression when used with immunosupressive agents, causes hyperkalaemia with potassium sparing diuretics, NSAID's may block the hypotensive action of the drug.



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions

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