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  Hydrocortisone

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General Systemic
Category Corticosteroid.


Pharmacokinetics

The bio-availablity of hydrocortisone is about 50 % after oral administration. It is metabolised in the hepatic microsomal enzymes. It is 90% plasma protein bound. The plasma half life is 1.5 hours.



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Indications

Hydrocortisone is used to reduce inflammation . It reduces swelling, erythema, pruritis, and allergic reactions. It is used in the treatment of severe allergies,skin problems and arthritis.It is used in shock, status asthmaticus and acute adrenal insufficiency.



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Routes of Administration and Dosage

Oral:20 mg in the morning+10 mgs in the afternoon. Parenteral:100 mgs I.V bolus followed by 100 mgs 8 hourly infusion.



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Contra Indications

Hydrocortisone is cotraindicated in viral/fungal infections, tubercular or syphilitic lesions, bacterial infections unless used in conjuction with appropriate chemotherapy.



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Precautions

Precaution has to be taken in CCF, hypertension, diabetes, epilepsy, CRF and in elderly. Longterm use of Hydrocotisone can cause cushing's habitus, hyperglycemia, muscular weakness, increased susceptibility to infection, delayed wound healing, and psychiatric disturbances.



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Interactions

Hydrocortisone has reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone and barbiturates. It has enhanced effect in women taking oral contraceptives.



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Brand Names

CORT-S[Neon Labs], EFCORLIN INJ[Allenburys], HSS[Shree Ganesh], LYCORTIN-S[Lyka], PRIMACORT[Macleods], WYCORT[Wyeth Lederie].



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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