Welcome, Guest    Sign in to Windows Live ID | Register  

  Industry Medical Portal |  Student Centre |  Sitemap |  Help 
FAQAbout Us |  Disclaimer & Legal |  Contact Us 

  Isosorbide Mononitrate

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Cardiovascular System
Category Anti Anginal and Coronary Vasodilator


Pharmacokinetics

When orally given it undergoes extensive first pass metabolism hence it is administered sublingualy.



Top

Indications

Nitrates are used to treat the symptoms of angina . Nitrates are used to treat angina in three ways: to relieve an attack that is occurring by using the drug when the attack begins; to prevent attacks from occurring by using the drug just before an attack is expected to occur; or to reduce the number of attacks that occur by using the drugs regularly on a long-term basis.



Top

Routes of Administration and Dosage

Oral: Initially 20mg 2-3 times daily upto 120mg daily in div. doses if required.



Top

Contra Indications

Contraindicated in Acute MI, Severe anaemia, cerebral haemorrhage, hypotension, obstructive cardiomyopathy, raised intra cranial tension and pregnancy.



Top

Precautions

Older adults:- Dizziness or lightheadedness may be more likely to occur in the elderly. Anemia (severe) and Glaucoma: May be worsened by nitrates. In Head injury (recent) and Stroke (recent): Nitrates may increase pressure in the brain, which may lead to worsening of the condition. In recent Myocardial Infarction : Nitrates may cause hypotension, which can aggravate problems associated with MI. In renal disease and hepatic disease : Effects may be increased because of slower removal of nitroglycerin from the body.



Top

Interactions

Orthostatic hypotension occurs when used together with: calcium channel blocker, antihypertensive, phenothiazine or tricyclic antidepressants.



Top

Brand Names

5 Mono ( Boichem), Angiocor (Novartis), Anginex (Wyeth Lederle), Angitrit (Unisearch), IHD (Stadmed), Imdur (Astra IDL), ISMO (Boehringer Mannheim), Isocor 20 (Merck), Isotec (Sertec), Isotrim (Pace SOL), Monicor (Wallace), Monit10 (Intas), Monit 20 (Intas), Monit OD (Intas), Monn (Natco), Monocontin 50 (Modi Mundipharma), Monomen (Menarini Raunaq), Monosorbitrate (Nicholas -Piramal), Monotrate (Sun Pharma), Monotrate OD (Sun Pharma), Nitro Fix (Carsyon0, Vasonit ( Recon), Vasotrate (Torrent).



Top

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

|

 

Advertisement
Tell us what you think about Web Health Centre - Send us your feedback
Copyright © 2017 WebHealthCentre. All rights reserved. Brought to you by