Welcome, Guest    Sign in to Windows Live ID | Register  

  Industry Medical Portal |  Student Centre |  Sitemap |  Help 
FAQAbout Us |  Disclaimer & Legal |  Contact Us 

  Nitrofurantoin

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Antibacterial


Pharmacokinetics

Nitrofurantoin is completely absorbed from the GIT and food favours its absorption. It doesn't reach therapeutic concentration in plasma but only in urine hence used in UTI. Its activity get lowered in alkaline urine.



Top

Indications

Nitrofurantoin belongs to the family of drugs called anti-infectives. It is used to treat infections of the urinary tract.



Top

Routes of Administration and Dosage

Oral dose: Adults and adolescents: 50 to 100 mg every six hours. Children up to 1 month of age: Use is not recommended. For the extended-release capsule dosage form: Adults and children 12 years of age and older: 100 mg every twelve hours for seven days.



Top

Contra Indications

Contraindicated in infants under 1 year of age, severe oliguria, anuria and in renal failure.



Top

Precautions

In Glucose-6-phosphate dehydrogenase (G6PD) deficiency: Nitrofurantoin may cause anemia in patients with G6PD deficiency. In renal disease (other than infection): The chance of side effects of this drug may be increased and the drug may be less effective in patients with renal disease. Pulmonary disease and nerve damage : Patients with pulmonary disease or nerve damage may have an increase in adverse effects when they take nitrofurantoin.



Top

Interactions

With Antidiabetics, Dapsone, Methyldopa, Primaquine, Procainamide, Quinidine,Sulfonamides,Sulfoxone,Vitamin K : Patients who take nitrofurantoin with any of these drugs develop blood disorders . With Carbamazepine, Chloroquine, Cisplatin, Diphtheria, tetanus, and pertussis (DTP) vaccine, Disulfiram, Ethotoin, Hydroxychloroquine, Lindane, Lithium and Vincristine: Patients who take nitrofurantoin with any of these drugs, or who have received a DTP vaccine within the last 30 days or are going to receive a DTP may have an increase in neurological adverse effects.



Top

Brand Names

Furadantin(Smithkline Beecham).



Top

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

|

 

Advertisement
Tell us what you think about Web Health Centre - Send us your feedback
Copyright © 2017 WebHealthCentre. All rights reserved. Brought to you by