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  Ofloxacin

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Gastrointestinal System, Genitourinary Tract
Category Antibiotic (Fluoroquinolones)


Pharmacokinetics

It is completely absorbed and is distributed throughout the body, it has elimination half life of 11hrs, and is excreted in the urine.



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Indications

Fluoroquinolones are used to treat bacterial infections in many different parts of the body. They are both bacteriocidal and bacteriostatic. It is effective against both gram positve and gram negative organisms including : Pseudomonas, Niesseria gonorrhoea,proteus mirablis, gonoccoci, Chlamydiae, E.coli, H.influenzae, staphylococci, streptococci etc. It is also active aginst some anaerobes. It is not effective for Rhinitis, Influenza, or other viral infections.They are mainly used for GIT infections.



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Routes of Administration and Dosage

Oral dose (tablets): Adults: 200 to 400 mg every twelve hours for three to ten days, depending on the medical problem being treated. Gonorrhoea is usually treated with a single, oral dose of 400 mg. Children up to 18 years of age: This drug is not recommended in infants, children, or teenagers. For injection dosage form: Adults: 200 to 400 mg every twelve hours for three to ten days, depending on the medical problem being treated. Gonorrhoea is usually treated with a single, oral dose of 400 mg. Children up to 18 years of age: This drug is not recommended in infants and children.



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Contra Indications

Contraindicated in children below 12yrs, convulsion, pregnancy, lactation and in hypersensitivity.



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Precautions

With Brain or spinal cord disease, including arterisclerosis in the brain or epilepsy or other seizures : Fluoroquinolones may cause neurological symptoms, renal impairment and hepatic disease: Patients with renal disease (alone) or renal disease and hepatic disease (together) may have an increased chance of side effects.



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Interactions

With : Antacids, Iron supplements or Sucralfate : These may keep Ofloxacin from being effective. Didanosine may reduce the effectiveness of Ofloxacin.



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Brand Names

Bestoflox(Bestochem), Oflin(Dee-Pharma), Oflin IV(Dee-Pharma), Tarivid(Hoechst Marion Roussel), Zanocin(Stancare).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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