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  Oxyphenbutazone

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems Musculoskeletal system
Category NSAID-Pyrazolone derivative.


Pharmacokinetics

When given orally Oxyphenbutazone is completely absorbed. It is 98% plasma bound. It is metabolised in the liver by hydroxylation and glucuronidation. The plasma t1/2 is nearly about 60hrs.



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Indications

Oxyphenbutazone is used in chronic inflammatory conditions like Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It is also used to suppress attacks of acute gout.



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Routes of Administration and Dosage

Oxyphenbutazone is given as 100- 200 mg tablets twice a day.



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Contra Indications

Oxyphenbutazone is contraindicated in hypersensitivity, active peptic ulcer due to increased chances of bleeding, moderate to severe hepatic disease and in pregnancy.



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Precautions

Precaution has to be taken in dyspepsia, hypertention and in lactation.



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Interactions

Oxyphenbutazone potentiates the action of anticoagulants like warfarin and oral hypoglycaemic agents. It increases the toxicity of Methotrexate by reducing its renal clearance and displacing it from it plasma protein. Oxyphenbutazone also inhibits the metabolism of Phenytoin and also reduces the hypotensive effect of beta-blockers.



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Brand Names

Phenabid(IDPL), Sioril(Albert David).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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