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  Prednisolone

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General Systemic
Category Corticosteroid.


Pharmacokinetics

The bio-availablity of prednisolone is about 50-80 % after oral administration. It is metabolized in the liver.



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Indications

Prednisolone is used to control the acute exacerbations of bronchial asthma, severe osteoarthritis, severe allergic reactions, atutoimmune diseases, and in rheumatoid arthritis.



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Routes of Administration and Dosage

Oral:5-60 mgs/day. 10-40 mgs I.M. or intra-articular. For long term therapy, the dose of prednisolone should not exeed 10 mgs per day.



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Contra Indications

Prednisolone is contraindicated in peptic ulcer, acute psychosis, cushing's syndrome, herpes simplex keratitis, CHF and in lactation.



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Precautions

Precaution has to be taken in diabetes, hypertention, Psychological disturbances, osteoporosis, post menopausal women, pregnancy and in chronic nephritis.Longterm use of Prednisolone can cause cushing's habitus, hyperglycemia, muscular weakness, increased susceptibility to infection, delayed wound healing, and psychiatric disturbances.



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Interactions

Efficacy of prednisolone is reduced by Aminoglutethimide, Antacids, Barbiturates, Carbamazepine, Griseofulvin, Mitotane, Phenylbutazone, Phenytoin, Primidone and Rifampin. Prednisolone reduces the amount of potassium in the blood. Digitalis can cause Cardiac arrhythmias if hypokalemia occurs. Immunization should be done very carefully. Skin test injections: Prenisolone may cause false results in skin tests. Sodium-containing drugs: Prednisolone causes edema, excess sodium may cause hypernatremia, hypertension, and water retention.



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Brand Names

DELTACORTIL (PFIZER), DEPO-MEDROL (MAX), HOSTACORTIN H ( HOECHST MARION RUSSEL), METYPRED ( CRITICARE), OMNACORTIL ( MACLEODS), SUCCIMEDROL (VHB), UNIDROL (UNISEARCH), WYSOLONE (WYETH LEDERLE)



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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