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  Progesterone

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions


Systems Endocrine, Reproductive systems
Category Hormone


Pharmacokinetics

Progesterone is not given orally as it becomes ineffective due to 1st pass metabolism. The analogs are more resistant to 1st pass metabolism and can be given orally. Injection in oil-base is effective intramuscularly. The 1/2 life of progesterone is a few minutes. It is metabolised to glucuronide or sulphate conjugates, which are excreted in the urine.



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Indications

It is used as an oral contraceptive, to treat DUB, dysmennorhea, pre-menstrual syndrome, endometriosis and threatened abortions.



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Routes of Administration and Dosage

Progesterone (as oily solution): 10-50 mg I.M. OD



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Contra Indications

It is contraindicated in hypersensitivity to the drug .



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Precautions

If given during pregnancy, masculinization of the female fetus can occur.



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Interactions

Interactions with other drugs are usually rare.



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions

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