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  Vitamin B12 (Cyanocobalamin)

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General Systemic
Category Vitamin


Pharmacokinetics

It is a water soluble vitamin. It is absorbed in the stomach by proteolysis with the help of Intrinsic Factor and is absorbed by active carrier transport mechanism .The Intrinsic Factor -B12 complex is absorbed in the terminal ileum. It is stored in the liver. It undergoes enterohepatic circulation and is excreted in small quantities in the urine.



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Indications

Vitamin B12 is used in conditions like Pernicious anaemia.It has been used in patients with neuropathies, psychiatric disorders and cutaneous sarcoid.



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Routes of Administration and Dosage

The daily recommended intake is: Infants and children: Birth to 3 years of age = 0.3-0.4 mcg, 4 to 6 years of age = 0.5 mcg, 7 to 10 years of age = 0.8-1 mcg, Adolescent and adults ; 1-2mcg.Pregnancy = 2-3 mcg Breast-feeding = 1.5-2.5 mcg. To treat P



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Contra Indications

Leber's disease: Vitamin B12 may make this condition worse



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Precautions

Anaphylactic reactions may occur on I.V injection, hence it should not be given I.V.



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Interactions

It rarely interacts with other drugs.



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Brand Names

REDISOL-H, REDISOL, MACRABIN-H, MACRABIN.



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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