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  Buprenorphine

Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names


Systems General (Systemic)
Category Opioid Analgesic[derived from thebain].


Pharmacokinetics

Buprenorphine can be given orally, IM, and sublingually. 50 % of the drug is bio-available after sublingual administration. It is highly protein bound and remains in the tissues for several days.It is mainly excreted in the faeces and in smaller amounts in the urine.



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Indications

Buprenorphine is indicated in moderate to severe pain in surgery, trauma, burns, fractures and cancer.



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Routes of Administration and Dosage

For injection dose : For pain in Adults: 0.3 milligrams (mg), injected IM or slow I.V .Can be repeated every six hours as required upto a maximum dose of 1.8mg.



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Contra Indications

Buprenorphine is contraindicated in severe respiratory disease and in pregnancy.



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Precautions

Special precaution to be taken in hepatic disease,renal disease and lactation.



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Interactions

May precipitate withdrawal symptoms in narcotic addicts. When given along with diazepam may produce respiratory and cardiac collapse.



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Brand Names

Buprigesic(Neon), Norphin(Unichem), Pentorel(khandelwal), Tidigesic(Sun Pharma).



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Pharmacokinetics | Indications | Routes of Administration and Dosage | Contra Indications | Precautions | Interactions | Brand Names

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